SUPARTZ® is used for the treatment of pain caused by osteoarthritis in patients who have failed to get relief from simple painkillers, or from exercise and physical therapy. When you have knee osteoarthritis the hyaluronic acid in the synovial fluid in your knee joint becomes diluted and breaks down—reducing its natural properties. This is associated with increased inflammatory processes that can degrade the cartilage in your knee. This inflammation causes pain receptors to begin firing during normal movement. The pain tends to cause patients with knee osteoarthritis to limit movement which in turn leads to further deterioration of joint structures and synovial fluid quality.